அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

A Novel Herbal Composition of Aqueous Extract of Capparis decidua and its Antinephrolithiasis Activity

Deepak Godara, Vichitra Kaushik, Gaurav Sharma and Vipin Saini

Kidney stone is similar to a small rock that forms in the kidney. Stones are formed when certain chemicals in the body clump together. A stone may stay in the kidney or travel through the urinary system. Small stones may pass through the urinary system without causing greatly pain. Bigger stones can block the flow of urine if they get trapped in the ureters or urethra. Kidney stones usually didn’t cause any symptoms until they start to pass. The present study was undertaken to investigate the anti nephrolithiasis activity of aqueous extract of Capparis decidua. Aqueous extract of Solanum xanthocarpum was administered via intraperitoneal route to albino wistar rat in two test doses 400mg/kg and 800 mg/kg. Experiment was performed for preventive and curative regimen. In preventive regimen aqueous extract of Capparis decidua (AECD) 800 mg/kg (57.35% relief) show greater creatinine clearance then standard drug cystone (34.54% relief) and in curative regimen cystone (125.33% relief) has greater effect then aqueous extract of Capparis decidua (AECD) 800 mg/kg (42.48% relief). Test drug show dose dependent therapeutic efficacy. Therapeutic effect of test drug increase with increasing dose.