Safaa Azzouz*, Jonathan How
We present a case of a previously healthy 61 year old female with a new diagnosis of Giant Cell Arteritis (GCA), initially treated with prednisone. One month later, she receives the diagnosis of Acute Myeloid Leukemia for which she gets a course of 7+3 induction chemotherapy. Clinicians need to be aware that large vessel vasculitis can be the first sign of a para-neoplastic syndrome related to a hematological malignancy. It has been hypothesized that blood malignancies such as leukemia are associated with depletion of the T-regulatory cells and overproduction of IL-6 and TNF-alpha. More research will need to be conducted in order to determine the relationship between GCA and DNA mutations such as in clonal hematopoiesis of indeterminate potential.
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