அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

Characterization and Release Kinetics of Microspheres and Tableted Microspheres of Diclofenac Sodium

Rawat Smriti, Bisht Seema & Kothiyal Preeti

This study reports the properties of tableted microparticles based ethylcellulose blend polymers as the controlled release system for diclofenac sodium (DS). Ethylcelulose blend microparticles are prepared through a solvent evaporation process which is a widely used microencapsulation technique in the pharmaceutical industry. The microspheres were characterized for their particle size and distribution, tapped density and encapsulation efficiency. Smaller sized particles with a narrow size distribution were produced with Ethylcellulose .The blend microparticles thus prepared were compressed into tablets using the directly compressible excipients. A cross-sectional view of the tablet reveals the presence of nearly spherical shaped particles in the tablet, suggesting that the system chosen is ideal for tableting. Drug release from compressed tablets was always faster than from uncompressed microspheres, but useful sustained-release characteristics were retained. Dissolution tests of formulations of the tableted microspheres showed increased release rate constants and decreased 50 per cent dissolution times compared to microspheres that had not been compressed. This result indicated that rupture of some of the microspheres had occurred. The drug release rate increased at higher compression pressures due to the rupture of a greater proportion of microspheres. Generally, the least compression pressure that gives tablets with acceptable properties is preferred.