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Characterization of Pancreatitis by Premature Intracellular Activation of Digestive Proteases within Pancreatic Acini

John D. Feuerste

This early activation could happen through a variety of methods. Calcium signalling in acinar cells may be disrupted, or trypsinogen may be broken down to trypsin by the lysosomal hydrolase cathepsin-B, or the intracellular pancreatic trypsin inhibitor's activity may be reduced. The most common symptom of acute pancreatitis is stomach discomfort, which is dull, boring, and consistent. Typically, the pain begins suddenly and steadily worsens until it becomes a chronic discomfort. The most common symptom of acute pancreatitis is stomach discomfort, which is dull, boring, and consistent. Typically, the pain begins suddenly and steadily worsens until it becomes a chronic discomfort.