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Clinicopathologic Findings of Pancreatic Neuroendocrine Tumors, a Single Center Experience

Bita Geramizadeh, Ali Kashkooe, Saman Nikeghbalian, Seyed-Ali Malekhosseini

Objectives Pancreatic neuroendocrine tumors are rare but they are being increased due to more accurate imaging techniques and better detection. There are reports from different Western countries regarding the clinicopathologic findings of this tumor; however fewer reports have been published from Asian countries. Overall there are not consistent reports regarding various characteristics of pancreatic NETs form different geographic areas of the world. Herein we report our experience during 5 years in 27 cases of pancreatic NETs. In our center as the largest referral center in the South of Iran, we investigated the clinicopathologic findings in pancreatic NETs. Patients and Methods During the study period (5 years) we evaluated 27 cases of pancreatic NETs. All of the clinicopathologic findings have been retrieved from their clinical charts. Patients’ follow up were available between 1 to 5 years. Results Among these 27 cases, 14 were male and 13 were female with a mean age of 47 years. The most common presenting symptom was epigastric pain. Amylase and lipase were mostly normal. Most common location was head of pancreas with a mean size of 4.5 cm. Seven patients had functional tumors. Most of the tumors were scored as grade 1 (low grade). Conclusion Majority of the clinicopathologic findings of pancreatic neuroendocrine tumors in our center was consistent with other reports from Asian countries.