அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

Immediate Release Formulation of Valsartan Capsule and Evaluation of its Compatibility by Nonthermal Methods

Sudhir. Maddela, Eswar Gupta. Maddi and Ramarao. Nadendla

Valsartan is a BCS class II antihypertensive drug whose bioavailability is dissolution rate limited. Various capsule formulations of valsartan were prepared using micro crystalline cellulose and sodium lauryl sulfate. Their dissolution profiles were compared with commercial marketed formulations. Formulation J was found to have similar t90 values to marketed brands statistically. Influence of sodium lauryl sulfate on the solubility of valsartan was studied and was found to increase with the concentration of sodium lauryl sulfate. Compatibility of valsartan with micro crystalline cellulose and sodium lauryl sulfate was studied by non-thermal methods like HPLC and IR.