அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

In-vivo Titanium Dioxide (TiO2) Nanoparticles Effects on Chromosomal Abnormalities and Lactate Dehydrogenase Activity

Javad Sharifi Rad, Mahsan Hoseini Alfatemi, Mehdi Sharifi Rad, Majid Sharifi Rad, Dhrubo Jyoti Sen and Sasan Mohsenzadeh

In this study we investigated effect of TiO2 nanoparticles on chromosomal abnormalities and lactate dehydrogenase activity and for this purpose nano anatase of titanium dioxide in four dosages of 10, 50, 100, 500, 800mg/Kg BW during intraperitoneal injection of male mice Balb/C were treated. After 24 hours, micronucleus test was carried out on the samples of bone marrow and determination of the Level of Lactate Dehydrogenase (LDH) level test performed on the samples of peripheral blood. Result showed that nano anatase of titanium dioxide in low dosage of 10, 50, 100mg/Kg BW, had not toxicity effects on bone marrow but in high dosages of 500, 800mg/Kg BW caused induced toxicity effect with increase micronucleus. In dosage of 10mg/Kg BW of nanoparticles showed LDH enzyme is blocked and a reduced in LDH level. The results of this study will be providing useful information for researcher to design of nanotechnology products with minimal side effects. This study can be very useful in reducing the complications of nanoparticle toxicity.