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Is Fluvoxamine Effective for Repetitive Behavior in Tic Disorder and Autism?

Xiaoyan Ma, Ranli Li, Feng Jia, Ying Wang, Jie Li

Emotional and behavioral abnormalities are prominent in mental disorders, especially in autism, tic disorder and Obsessive-Compulsive Disorder (OCD). Repetitive behavior seems to be characteristic of them. It is difficult to distinguish stereotyped or compulsive-like behavior for diverse clinical symptoms exhibited in these patients. Selective Serotonin Reuptake Inhibitor (SSRIs) was recommended as the first line in treatment for OCD. Fluvoxamine was a good choice for OCD especially in children. Behavior and emotion were improved under therapy with SSRIs including fluvoxamine in autism and tic disorder. Moreover, the disease get remission is also based on improvement in behavior and emotion. Repetitive behavior seems to be common feature of autism, tic disorder and OCD. It also plays a key role in therapy and prognosis of the disease. Behavior improved in our report cases treated with fluvoxamine, so fluvoxamine maybe a good choice for abnormal behavior regardless of the diagnosis of the disease. However, a clinical study in a larger sample is needed to confirm its efficacy in patients with abnormal behavior especially with repetitive behavior and to elucidate the mechanism underlying its effect.