அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

Synthesis and Antimicrobial Screening of Some Azetidine Derivatives

Rakesh Patel and Anil Bhandari

New series of N-(3-chloro-2-oxo-4-substituted-azetidine-1-yl) isonicotinamide derivatives were synthesized by the reaction of Schiff base with 2-chloroacetic acid. Synthesized compounds were evaluated for their Anti-bacterial activity against staphylococcus aureus and Echerichia coli, Antifungal activity against C Albicans and Anti-tubercular activity against mycobacterium tuberculosis. Synthesized compounds show significant activity against bacterial, fungal and mycobacterium strains. Their structures were established on the basis of elemental analysis, IR, 1H NMR and Mass Spectral data.