அமெரிக்கன் ஜர்னல் ஆஃப் அட்வான்ஸ்டு மருந்து டெலிவரி திறந்த அணுகல்

சுருக்கம்

Synthesis, Characterization and Study Antibacterial Activity of Some New Fused Pyrazol Pyrimidin Derivatives

Ezzat H. Zimam

New series of 2-heterocycle-substituted benzimidazole having a pyrazolo [3, 4-d] pyrimidine nucleus have been synthesized by reacting 2-(chloromethyl) benzimidazole with hydrazine hydrate to form compound (1). The vital compound in this synthesis 1- ((benzoimidazol-2-yl)methyl)-3-methyl-pyrazol-5-one was obtained by reacting compound (1) with ethyl acetoacetate, and was used in the Biginelli multi-component cyclo condensation reaction with eight derivatives of benzaldehyde in presence of urea to form pyrimidine derivatives (3-10). The products were characterized by C.H.N analyses, I.R spectra and 1HNMR spectrum. Antibacterial activity of some prepared compounds against two types of bacteria: Staphylococcus aureus (Gram positive) and Pseudomonas aeruginosa (Gram negative). Some the compounds showed high inhibition activity against bacteria.